Mass Spectrometry and Hyphenation

Introduction to mass spectrometry and its use with different hyphenations. Focus on the different ionisation techniques used, together with different analysers. Throughout the construct of the molecule is used to direct the user to the correct ionisation and sample introduction technique(s). The need to understand and use the correct nomenclature and performance criteria of the mass spectrometer and related experiments is also stressed, thus allowing for clear communication of experiments and results. Strategies for data interpretation, together with some simple mechanistic approaches to fragmentation are shown with this linking to basic tandem MS, these include understanding the behaviour of odd electron and even electron species.

Presenter: John Langley

Professor John Langley is an expert in mass spectrometry and chromatography, researching complex systems through the application and development of different analytical approaches. John has over 130 peer-reviewed publications (more than 150 in Google Scholar) and an H-index of 35 and has published in over 30 leading scientific journals, reflecting the multidisciplinary nature of the applications of his research activity.

John has 40 years of experience in the academic sector and specializes in the application of separation science and mass spectrometry as a research tool for chemistry, chemical biology, and oilfield chemistry, addressing complexity and probing new research areas. Specific interests are the application of hyphenated approaches (GC-MS, GCxGC-MS, HPLC-MS, LCxLC-IMS-MS, MS/MS, SFC-MS and SFC-FID).

John has 30 years of sustained research funding with RCUK and industry, (including AZ, BP, GSK, Innospec, and Syngenta) and was awarded the Chromatographic Society Jubilee Medal 2024 and the British Mass Spectrometry Society Medal 2021.

For a better understanding of the course format, view the first module below:

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